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FGF/FGFR signaling pathway involved resistance in various cancer types

Yangyang Zhou1, Chengyu Wu1, Guangrong Lu2

  • 1Department of Rheumatology and Immunology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

Journal of Cancer
|March 5, 2020
PubMed

Insights

Fibroblast growth factor (FGF)/receptor (FGFR) signaling drives cancer treatment resistance. Understanding FGF/FGFR mechanisms is crucial for overcoming resistance to chemotherapy, radiotherapy, and targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cancer treatment resistance is a significant clinical challenge.
  • Fibroblast growth factor (FGF)/receptor (FGFR) signaling is implicated in oncotherapy resistance.
  • Understanding resistance mechanisms is vital for improving patient outcomes.

Purpose of the Study:

  • To review the mechanisms of FGF/FGFR signaling in mediating resistance to various cancer treatments.
  • To summarize the known mechanisms of resistance to FGF/FGFR inhibitors in cancer.

Main Methods:

  • Literature review of studies on FGF/FGFR signaling and cancer resistance.
  • Analysis of underlying molecular mechanisms.
  • Synthesis of findings on resistance to chemotherapy, radiotherapy, targeted therapy, and FGF/FGFR inhibitors.

Main Results:

  • FGF/FGFR signaling plays a critical role in resistance to chemotherapy, radiotherapy, and targeted therapy across diverse cancers.
  • Mechanisms of resistance to FGF/FGFR inhibitors have been identified.

Conclusions:

  • Targeting FGF/FGFR signaling pathways is a potential strategy to overcome cancer treatment resistance.
  • Further research into FGF/FGFR-mediated resistance is needed to develop more effective cancer therapies.
Keywords:
FGF/FGFRFGF/FGFR inhibitorsoncotherapyresistance

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