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Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with

Dewa Ayu Swastini1, Ida Ayu Dewi Wiryanthini2, Ni Luh Putu Ariastuti2

  • 1Department of Pharmacy, Udayana University, Denpasar, Bali, Indonesia.

Open Access Macedonian Journal of Medical Sciences
|March 5, 2020
PubMed

Insights

High Sensitivity C-Reactive Protein (hs-CRP) correlates with atherosclerosis severity. High triglyceride and BMI are key factors influencing hs-CRP levels in dyslipidemia patients, indicating their role in cardiovascular risk.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Atherosclerosis Research

Background:

  • Inflammation is central to atherosclerosis development and progression.
  • High Sensitivity C-Reactive Protein (hs-CRP) is a marker of systemic inflammation and a predictor of cardiovascular events.

Purpose of the Study:

  • To assess the independent role of hs-CRP in predicting atherosclerosis severity.
  • To identify factors influencing hs-CRP levels in patients with dyslipidemia.

Main Methods:

  • 388 patients (267 dyslipidemia, 121 controls) were studied.
  • Atherosclerosis severity was measured using ankle-brachial index (ABI) and Doppler ultrasound.
  • Risk factors including age, gender, diabetes, smoking, hypertension, lipids, and glucose were analyzed for their association with hs-CRP.

Main Results:

  • A significant association was found between hs-CRP levels and atherosclerosis severity (p < 0.01).
  • Triglyceride, fasting plasma glucose, and BMI positively correlated with hs-CRP.
  • HDL cholesterol showed a negative correlation with hs-CRP.
  • Multivariate analysis identified triglyceride and BMI as major determinants of hs-CRP levels.

Conclusions:

  • Hs-CRP levels correlate with the extent of atherosclerosis.
  • Elevated triglyceride and BMI are strongly associated with higher hs-CRP levels in dyslipidemia patients.
Abstract

Keywords:
AtherosclerosisDyslipidemiaHs-CRP

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