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Fatal outcome of first case of Streptococcus sinensis in infective endocarditis in the Netherlands: a case report
Anne Margje Lisa Naomi van Ommen1, Serena Slavenburg2, Rob Diepersloot1
1Diakonessenhuis, Bosboomstraat 1, Postal Box 80250, 3508 TG Utrecht, the Netherlands.
Background:
Infective endocarditis is a relatively common disease in a cardiologist's daily practice. Nowadays more detailed information about pathogens is provided to us by diagnostics such as MALDI Biotyper Massa Spectrometer. We present a case of endocarditis lenta in which Streptococcus sinensis was identified in the Netherlands for the first time.
Case Summary:
A 58-year-old man was admitted with high suspicion of endocarditis lenta complicated by severe kidney dysfunction and anaemia. He was treated with penicillin and gentamycin. Transthoracic echocardiogram revealed a large vegetation at the mitral valve and MALDI Biotyper Massa Spectrometer (Microflex) revealed S. sinensis as the pathogen. The patient refused to receive blood transfusions or surgery. Due to cerebral infarction with haemorrhagic transformation, the patient died 8 days after admission.
Discussion:
Streptococcus sinensis was described in Hong Kong for the first time and is associated with endocarditis in rheumatic heart disease. To our knowledge, this is the first case reporting a fatal outcome of endocarditis due to this bacterium in the acute phase. In this case, late discovery, disease severity, and under treatment all contributed to the poor outcome. We want to share the knowledge on the existence of this bacteria.
Insights
This case report details the first identification of Streptococcus sinensis causing endocarditis lenta in the Netherlands. The patient experienced a fatal outcome due to late diagnosis and disease severity.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Infective endocarditis is a significant clinical challenge.
- Advanced diagnostics like MALDI Biotyper Massa Spectrometer enhance pathogen identification.
- Streptococcus sinensis is an emerging pathogen in endocarditis.
Observation:
- A 58-year-old male presented with endocarditis lenta, severe renal dysfunction, and anemia.
- Echocardiography showed a large mitral valve vegetation.
- MALDI Biotyper Massa Spectrometer identified Streptococcus sinensis.
Findings:
- This is the first reported case of Streptococcus sinensis-induced endocarditis lenta in the Netherlands.
- The patient experienced a fatal outcome despite antibiotic treatment.
- Factors contributing to the poor outcome included late discovery, disease severity, and treatment limitations.
Implications:
- Highlights the emergence of Streptococcus sinensis as a cause of infective endocarditis.
- Underscores the importance of timely diagnosis and appropriate management of endocarditis.
- Emphasizes the need for awareness of this pathogen in clinical practice.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis III: Medical Management
Endocarditis IV: Nursing Management
Rheumatic Heart Disease I: Introduction
Streptococcal Pharyngitis

