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Unconventional Estrogen Signaling in Health and Disease

Christina L Faltas1, Kira A LeBron1, Marina K Holz1

  • 1Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY.

Endocrinology
|March 5, 2020
PubMed

Insights

Estrogen is vital for tissue homeostasis and gene regulation in both sexes. This review explores its less-known functions in maintaining health and disease processes.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cell Biology

Background:

  • Estrogen is a critical hormone regulating gene expression, metabolism, and cell growth.
  • Estrogen acts via estrogen receptors, influencing cytoplasmic signaling and nuclear transcription.
  • Dysregulated estrogen activity is implicated in numerous diseases.

Purpose of the Study:

  • To review the unconventional roles of estrogen.
  • To highlight estrogen's involvement in homeostasis and disease pathogenesis.

Main Methods:

  • Literature review of estrogen's functions.
  • Analysis of estrogen's impact on cellular pathways.
  • Exploration of estrogen's role in disease.

Main Results:

  • Estrogen exhibits diverse, often overlooked, functions beyond traditional roles.
  • Estrogen significantly impacts cellular processes relevant to homeostasis.
  • Aberrant estrogen signaling contributes to disease development.

Conclusions:

  • Estrogen possesses multifaceted roles in physiological and pathological conditions.
  • Understanding unconventional estrogen functions is crucial for disease management.
  • Further research into estrogen's complex mechanisms is warranted.
Keywords:
cardiovascular diseasediabetesdiseaseestrogenlymphangioleiomyomatosis

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