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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Stem cell therapy: old challenges and new solutions.

Carmela Rita Balistreri1, Elena De Falco2,3, Antonella Bordin2

  • 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Palermo, Italy. carmelarita.balistreri@unipa.it.

Molecular Biology Reports
|March 5, 2020
PubMed
Summary
This summary is machine-generated.

Stem cell therapy (SCT) shows promise but needs further development. Advances in understanding stem cell biology and technology aim to improve retention, survival, and integration for treating chronic diseases.

Keywords:
3D systemsBio-nanotechnologyBioprintingExosomesRegenerative medicineStem cell therapy

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Pharmacology

Background:

  • Stem cell therapy (SCT) is a potential alternative to traditional pharmacological treatments.
  • Current SCT faces challenges including cell retention, survival, and integration.
  • Stem cells are not yet considered a standard therapeutic agent due to their unique biology.

Purpose of the Study:

  • To review recent advances in stem cell biology and technology.
  • To discuss strategies for overcoming current limitations in SCT.
  • To explore the potential for extending the clinical applicability of SCT for chronic diseases.

Main Methods:

  • Review of current literature on stem cell biology and therapeutic applications.
  • Discussion of emerging technologies and interdisciplinary approaches.
  • Analysis of methods to enhance stem cell retention, survival, and integration.

Main Results:

  • A new orientation in SCT is emerging, driven by enhanced biological understanding and advanced technologies.
  • Pharmacology, genetic manipulation, and biomaterial incorporation are key strategies to address SCT challenges.
  • These advancements are expected to improve the effectiveness and success of SCT.

Conclusions:

  • Stem cell therapy holds significant potential for a medical revolution in treating chronic human diseases.
  • Continued research and technological innovation are crucial for realizing the full clinical potential of SCT.
  • Addressing current limitations will extend the effectiveness and success of stem cell treatments.