Related Experiment Videos
Hepatitis and copper accumulation in Skye terriers
S Haywood1, H C Rutgers, M K Christian
1Department of Veterinary Pathology, University of Liverpool, UK.
Veterinary Pathology
|November 1, 1988
Summary
Skye terrier hepatitis involves liver damage and excess copper accumulation. This distinct canine liver disease may stem from impaired bile metabolism and secretion.
Area of Science:
- Veterinary Pathology
- Canine Hepatology
- Toxicology
Background:
- Canine liver disease presents diverse pathologies.
- Skye terriers exhibit a unique form of hepatitis.
- Copper accumulation is implicated in certain liver conditions.
Purpose of the Study:
- To investigate histological changes and copper content in Skye terriers with liver disease.
- To characterize the distinct features of Skye terrier hepatitis.
- To explore the relationship between copper levels and liver pathology in this breed.
Main Methods:
- Histopathological examination of liver tissues from nine affected Skye terriers.
- Quantification of copper content in liver samples.
- Correlation analysis between histological findings and copper levels.
Main Results:
- Liver lesions varied from hepatocellular degeneration and necrosis to chronic hepatitis, cholangioplasia, and cirrhosis.
- Significantly elevated copper levels (801-2,257 µg/g) were observed.
- Excess copper correlated with the severity of cholestasis.
Conclusions:
- Skye terrier hepatitis is a distinct disease entity.
- The condition is likely linked to a disorder of intracellular bile metabolism.
- Disturbed bile secretion and subsequent copper accumulation are key features.