The Banting Memorial Lecture 1976. Insulin today

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Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain.

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Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.

Proceedings of the National Academy of Sciences of the United States of America·2002

Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP.

Molecular medicine (Cambridge, Mass.)·2001

Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.

The Journal of biological chemistry·2001

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

Diabetes·2001

The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions.

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Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice.

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Metabolic Blockade of Glycolysis Diminishes Autoreactive CD4 T-Cell Effector Responses in Type 1 Diabetes.

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Myeloid-Specific Heparanase Aggravates Insulitis in Type 1 Diabetes via Heparan Sulfate Fragment-Dependent Amplification of Macrophage Polarization.

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A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action.

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Dual Modulation of Prostaglandin E2 Receptors EP3 and EP4 Protects β-Cell Mass in a Model of Aggressive Autoimmune Inflammation.

Diabetes·2026

Preliminary testing of a prespecified liability architecture for autism: theory-guided pathogenetic triad models outperform strength-matched alternatives.

Frontiers in psychiatry·2026

Behavioral Complexity in Alzheimer's Disease: A Diversity-Based Analysis of Neuropsychiatric Symptoms.

Brain sciences·2026

Unique environmental and familial influence on amygdalar hyperresponsivity in post-traumatic stress disorder - a discordant monozygotic twin study.

Biological psychiatry·2026

The Wistar-Kyoto rat as a model relevant to inattentive ADHD: substrain variability and affective comorbidity.

Pharmacological reports : PR·2026

A Systematic Review of the Characterization of Behavior in Canine Behavioral Questionnaires.

Journal of applied animal welfare science : JAAWS·2026

A case of cannibalistic behaviour in psychosis: Clinical and forensic considerations.

Journal of forensic and legal medicine·2026

Related Experiment Videos

The Banting Memorial Lecture 1976. Insulin today

Related Concept Videos

A brief perspective on insulin production.

Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures in rat brain.

Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.

Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP.

Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.

The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site.

The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions.

Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice.

Metabolic Blockade of Glycolysis Diminishes Autoreactive CD4 T-Cell Effector Responses in Type 1 Diabetes.

Myeloid-Specific Heparanase Aggravates Insulitis in Type 1 Diabetes via Heparan Sulfate Fragment-Dependent Amplification of Macrophage Polarization.

A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action.

Dual Modulation of Prostaglandin E2 Receptors EP3 and EP4 Protects β-Cell Mass in a Model of Aggressive Autoimmune Inflammation.

Preliminary testing of a prespecified liability architecture for autism: theory-guided pathogenetic triad models outperform strength-matched alternatives.

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Unique environmental and familial influence on amygdalar hyperresponsivity in post-traumatic stress disorder - a discordant monozygotic twin study.

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The Banting Memorial Lecture 1976. Insulin today

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