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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

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Evaluation of the relationship between blood cell parameters and vascular calcification in dialysis-dependent

Abhilash Chandra1, Gaurav Raj2, Namrata P Awasthi3

  • 1Department of Nephrology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|March 5, 2020
PubMed

Insights

Coronary artery calcification (CAC) and thoracic aorta calcification (TAC) are linked to higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in end-stage renal disease (ESRD) patients. These blood cell parameters may aid cardiovascular risk assessment in ESRD.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Coronary artery calcification (CAC) is a key cardiovascular risk marker in end-stage renal disease (ESRD).
  • Vascular calcification (VC) is prevalent in ESRD patients on dialysis.
  • Predictive markers for VC in ESRD are crucial for risk stratification.

Purpose of the Study:

  • To investigate the association and predictive value of blood cell parameters with coronary and thoracic aorta vascular calcification (VC) in ESRD patients on dialysis.
  • To evaluate the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting VC in this population.

Main Methods:

  • Study included ESRD patients (18-60 years) on hemodialysis or peritoneal dialysis, excluding those with active infections, inflammatory diseases, or pre-existing cardiovascular conditions.
  • Coronary aorta calcification (CAC) score (CACS) and thoracic aorta calcification (TAC) score (TACS) were assessed using Agatston scoring.
  • Multivariate logistic and linear regression analyses were performed to identify predictors of VC.

Main Results:

  • Patients with VC were older and had significantly higher NLR and PLR compared to those without VC.
  • Increasing age and higher PLR were associated with an increased likelihood of VC on multivariate analysis.
  • Age, NLR, and PLR showed significant positive correlations with CACS and TACS. Red cell distribution width also predicted TACS.

Conclusions:

  • NLR and PLR are associated with coronary and thoracic aorta vascular calcification in ESRD patients on dialysis.
  • These readily available blood parameters, particularly PLR, show promise for cardiovascular risk assessment in ESRD, especially in the 30-60 age group.

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