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Updated: Dec 27, 2025
04:02
Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
Published on: November 25, 2025
103
Chronic calculus cholecystitis: Is histopathology essential post-cholecystectomy?
Amul K Butti1, Shakti K Yadav1, Alekh Verma1
1Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India.
Indian Journal of Cancer
|March 5, 2020
Summary
Routine histopathology of cholecystectomy specimens is crucial for detecting incidental gall bladder cancers (GBCs). Microscopic examination of all specimens can be reserved for those with macroscopic lesions, reducing costs and workload.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Background:
- Gall bladder carcinoma (GBC) is a common gastrointestinal malignancy.
- Incidental GBCs are found in 1% of cholecystectomy specimens.
Purpose of the Study:
- To evaluate the utility of routine histopathology for cholecystectomy specimens.
- To assess the diagnostic accuracy of macroscopic abnormalities in detecting invasive GBC.
Main Methods:
- Retrospective review of 906 cholecystectomy histopathology records.
- Cases categorized into Group A (gross abnormality) and Group B (normal appearance).
- Analysis of demographic, gross, and microscopic findings.
Main Results:
- Sensitivity: 85.71%, Specificity: 95.44% for macroscopic abnormality in diagnosing invasive GBC.
- Positive Predictive Value (PPV): 91.11%, Negative Predictive Value (NPV): 99.65%.
- One invasive GBC case identified in a macroscopically normal specimen (Group B).
Conclusions:
- Histopathological examination of all cholecystectomy specimens is recommended.
- Microscopic processing may be prioritized for specimens with macroscopic lesions.
- This approach can reduce costs and pathology workload without impacting patient care.
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