Related Experiment Video
Updated: Dec 27, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids
Yong Shen1, Wen-Juan Liang2, Ya-Na Shi3
1College of Agronomy and Biotechnology, Yunnan Agricultural University, Kunming, 650201, P. R. China and Biocontrol Engineering Research Center of Plant Disease and Pest, Yunnan University, Kunming, 650504, P. R. China. zhaodk2012@ynu.edu.cn and Biocontrol Engineering Research Center of Crop Disease and Pest, Yunnan University, Kunming, 650504, P. R. China and School of Life Science, Yunnan University, Kunming, 650504, P. R. China and Kunming Kangren Biotechnology Co., Ltd., Kunming, 650203, P. R. China and Research & Development Center for Functional Products, Yunnan Agricultural University, Kunming, 650201, P. R. China.
Abstract:
Covering: 2009 to 2018. Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, are a diverse class of compounds having complex structural features with many stereocenters. The important pharmacological activities and structural complexity of the diterpenoid alkaloids have long interested scientists due to their medicinal uses, infamous toxicity, and unique biosynthesis. Since 2009, 373 diterpenoid alkaloids, assigned to 46 skeletons, have been isolated and identified from plants mostly in the Ranunculaceae family. The names, classes, molecular weight, molecular formula, NMR data, and plant sources of these diterpene alkaloids are collated here. This review will be a detailed update of the naturally occurring diterpene alkaloids reported from the plant kingdom from 2009-2018, providing an in-depth discussion of their diversity, biological activities, pharmacokinetics, toxicity, application, evolution, and biosynthesis.
More Related Videos
09:36Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Opioid Receptors: Overview
Fungal Phylum Basidiomycota
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Opioid Analgesics: Morphine and Other Natural Cogeners