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Association between serum adiponectin concentrations and chronic obstructive pulmonary disease: a meta-analysis
Yi-Hua Lin1, Tian-Xiang Jiang2, Su-Xian Hu1
1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
Serum adiponectin levels are elevated in patients with chronic obstructive pulmonary disease (COPD). This meta-analysis confirms higher adiponectin in COPD patients compared to controls, including stable and acute exacerbation phases.
Area of Science:
- Biochemistry
- Pulmonology
- Medical Research
Background:
- Adiponectin's role in chronic obstructive pulmonary disease (COPD) pathophysiology is under investigation.
- Previous studies on serum adiponectin concentrations in COPD patients yielded inconsistent results.
- A meta-analysis was conducted to clarify the association between serum adiponectin and COPD.
Purpose of the Study:
- To systematically evaluate the association between serum adiponectin concentrations and COPD.
- To synthesize findings from multiple studies to provide a more robust conclusion.
Main Methods:
- A comprehensive literature search was performed across PubMed, Embase, Web of Science, and Cochrane Library.
- Data from eligible studies were extracted for analysis.
- Standard mean differences (SMDs) and 95% confidence intervals (CIs) were calculated to quantify the effect size.
Main Results:
- Thirteen studies comprising 1131 COPD cases and 689 controls were included.
- Serum adiponectin levels were significantly higher in COPD patients than in controls (SMD: 1.09, 95% CI [0.73-1.45], P < 0.001).
- Elevated adiponectin was observed in stable COPD, AECOPD, and mixed COPD patient groups, with higher levels in AECOPD compared to stable COPD.
Conclusions:
- This meta-analysis provides strong evidence that patients with COPD exhibit higher serum adiponectin concentrations compared to healthy individuals.
- The findings support adiponectin as a potential biomarker in COPD.
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