Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.5K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

505
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
505
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Synthetic Biology02:55

Synthetic Biology

5.4K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.4K
Proteomics01:33

Proteomics

9.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.2K
Ribosome Profiling02:24

Ribosome Profiling

4.0K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Agnostic material classification using differential de Bruijn graphs of DNA imprints.

bioRxiv : the preprint server for biology·2026
Same author

Identifying membrane-bound transcriptional regulatory proteins from rare but evolutionarily conserved domain combinations.

Nucleic acids research·2026
Same author

A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural complexes.

Cell reports·2026
Same author

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases.

Cell genomics·2026
Same author

Structural and kinetic insights into a metagenomics-derived Cas12a with high specificity.

bioRxiv : the preprint server for biology·2026
Same author

Phage-encoded factor stimulates DNA degradation by the Hna anti-phage defense system.

Nature communications·2026

Related Experiment Video

Updated: Dec 27, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.9K

Structural Biology in the Multi-Omics Era.

Caitlyn L McCafferty1, Eric J Verbeke1, Edward M Marcotte1,2,3

  • 1Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, United States.

Journal of Chemical Information and Modeling
|March 5, 2020
PubMed
Summary

Cryo-electron microscopy and mass spectrometry enable structural-omics for complex protein mixtures. Advances in sample prep, data processing, and modeling are key to understanding cellular structures.

More Related Videos

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.6K
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.5K

Related Experiment Videos

Last Updated: Dec 27, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.9K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.6K
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.5K

Area of Science:

  • Structural biology
  • Biophysics
  • Biochemistry

Background:

  • Cryo-electron microscopy (cryo-EM) allows studying protein structures in near-native states.
  • Single-particle analysis is increasingly applied to heterogeneous mixtures.
  • Structural-omics combines cryo-EM and mass spectrometry for comprehensive analysis.

Purpose of the Study:

  • To highlight advances and challenges in structural-omics for complex mixtures.
  • To discuss the potential of these methods for cellular-level structural biology models.

Main Methods:

  • Cryo-electron microscopy (cryo-EM) for high-resolution imaging.
  • Single-particle analysis (SPA) for heterogeneous samples.
  • Mass spectrometry (MS) for complementary structural information.

Main Results:

  • Demonstrated potential of combining cryo-EM and MS for complex biological systems.
  • Identified key areas for improvement in sample preparation and data processing.
  • Showcased progress in molecular modeling for interpreting complex structural data.

Conclusions:

  • Structural-omics approaches are powerful for analyzing complex protein assemblies.
  • Overcoming challenges in sample prep and data analysis is crucial for broader application.
  • These methods promise to advance cellular-level structural biology.