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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Beyond mineralisation: metabolic functions for matrix mineralisation regulators.
Fiona Roberts1, Greg Markby1, Scott Dillon1
1Functional Genetics and Development, The Roslin Institute, The University of Edinburgh, Edinburgh, UK.
The Journal of Endocrinology
|March 5, 2020
Summary
Mineralization regulators balance skeletal and soft tissue health. Understanding their non-skeletal roles in diseases like diabetes and cardiovascular disease may reveal new therapeutic targets.
Area of Science:
- Biochemistry
- Physiology
- Pathology
Background:
- Skeletal and soft tissue mineralization are regulated by a balance of promoting and inhibiting factors.
- Emerging research suggests these regulators have non-skeletal roles in various human diseases.
Purpose of the Study:
- This review focuses on the functional roles and mechanisms of endocrine factors, phosphatases, and phosphodiesterases in pathologies.
- To explore the potential of identifying druggable targets for metabolic syndrome and related morbidities.
Main Methods:
- Literature review of studies on mineralization regulators.
- Analysis of emerging research on non-skeletal functions.
Main Results:
- Mineralization regulators play critical roles beyond skeletal health.
- These factors are implicated in diabetes, cardiovascular disease, obesity, and neurodegenerative diseases.
Conclusions:
- Understanding the extra-skeletal mechanisms of mineralization regulators is crucial.
- Targeting these pathways offers potential for treating metabolic and other common diseases.
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