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[Neurologic complications in malignant lymphoma].

E Nedelcheva, L Popova, E Khadzhiev

    Vutreshni Bolesti
    |January 1, 1988
    PubMed
    Summary

    Central nervous system involvement in malignant lymphoma affects 8.9% of patients. Early detection and combined treatment, including polychemotherapy and intrathecal cytarabine, improve outcomes for lymphoma patients with CNS complications.

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    Vnitrni lekarstvi·2004

    Area of Science:

    • Oncology
    • Neurology

    Context:

    • Malignant lymphomas can affect the central nervous system (CNS).
    • Understanding CNS involvement patterns and risk factors is crucial for patient management.

    Purpose:

    • To investigate the incidence, clinical manifestations, and prognostic implications of central nervous system involvement in patients with malignant lymphoma.

    Summary:

    • A five-year study of 235 malignant lymphoma patients revealed CNS involvement in 8.9% (20 patients).
    • Manifestations included spinal cord compression (13), meningosis (5), and cerebral infiltrations (2).
    • Risk factors for meningeal involvement included young age, retroperitoneal lymph nodes, high-grade lymphomas, and extranodal sites.

    Impact:

    • Meningeal involvement, particularly meningosis, is associated with poor prognosis, highlighting the need for meningeal prophylaxis in at-risk groups.
    • Spinal cord compression prognosis depends on overall lymphoma spread, not the complication itself.
    • Timely diagnosis and combined treatment (polychemotherapy with intrathecal cytarabine) yield favorable results.

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