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Evolving challenges to model human diseases for translational research.

Amanda P Beck1, David K Meyerholz2

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This summary is machine-generated.

The use of animal models in biomedical research is evolving, with large animal models like pigs becoming more prominent alongside traditional rodents. This shift presents new challenges and opportunities in translational studies.

Keywords:
Animal modelsBiomedical researchLarge animal modelsTranslationTranslational studies

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Area of Science:

  • Biomedical Research
  • Translational Science

Background:

  • Rodent models have traditionally dominated biomedical research.
  • Recent advancements have increased the utility of large animal models, such as pigs, in translational studies.
  • The landscape of animal modeling is undergoing significant evolution.

Purpose of the Study:

  • To highlight the changing dynamics in animal model selection for research.
  • To address the implications of evolving animal models on research infrastructure and execution.
  • To emphasize the need for researchers to justify and communicate the value of their chosen animal models.

Main Methods:

  • Review of current trends in animal model utilization.
  • Analysis of the impact of new animal model species on research practices.
  • Discussion of challenges and considerations for implementing diverse animal models.

Main Results:

  • The increasing application of large animal models signifies a shift from traditional rodent models.
  • Evolving animal models necessitate adaptations in research facilities, expertise, reproducibility, and funding.
  • New challenges arise in managing diverse animal models within the research ecosystem.

Conclusions:

  • Researchers must adapt to the expanding range of animal models available for biomedical studies.
  • The integration of diverse animal models requires strategic planning regarding resources and scientific rigor.
  • Effective communication of the necessity and value of animal research to the public is crucial.