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Updated: Dec 27, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
Published on: June 2, 2021
Objective evaluation for treat to target in Crohn's disease
Kento Takenaka1,2, Yoshio Kitazume3, Toshimitsu Fujii4
1Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. ktakenaka.gast@tmd.ac.jp.
Background:
Crohn's disease (CD) is a chronic and destructive bowel disease; continued disease activity can lead to penetrating complications. With the recent advent of effective medications, the importance of using a treat-to-target approach to guide therapy is becoming important.
Methods:
In this review, we reviewed the previous evidence for evaluating CD lesions.
Results:
We describe ileocolonoscopy's role in assessing disease activity, as well as recent progress in modalities, such as balloon-assisted endoscopy, capsule endoscopy, magnetic resonance enterography, computed tomography enterography, and ultrasonography. Advances in modalities have changed CD assessment, with small-bowel involvement becoming more important.
Conclusions:
Proper optimization is necessary in clinical practice.
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