TNF-α polymorphisms might influence predisposition to periodontitis: A meta-analysis.

Area of Science:

• Genetics
• Immunology
• Periodontology

Background:

• The link between Tumor Necrosis Factor-alpha (TNF-α) gene polymorphisms and periodontitis susceptibility remains debated.
• Previous studies yielded controversial and ambiguous findings regarding this association.

Purpose of the Study:

• To conduct a comprehensive meta-analysis to clarify the relationship between TNF-α polymorphisms and periodontitis.
• To pool data from existing studies to provide a more precise estimation of the genetic association.

Main Methods:

• Systematic literature search across major databases (PubMed, Embase, Web of Science, CNKI).
• Inclusion and statistical pooling of data from 45 relevant published studies.
• Subgroup analysis focusing on Asian populations and Bonferroni correction for multiple comparisons.

Main Results:

• Significant associations were observed between TNF-α polymorphisms (rs361525, rs1800629, rs1800630, rs1799964) and periodontitis risk in the general population.
• Subgroup analysis in Asians confirmed significant associations for rs361525, rs1800629, rs1800630, and rs1799964.
• After Bonferroni correction, rs361525, rs1800629, and rs1799964 remained significantly associated, while the association for rs1800630 became non-significant.

Conclusions:

• TNF-α polymorphisms rs361525, rs1800629, and rs1799964 are likely associated with an increased predisposition to periodontitis.
• The association appears particularly pronounced in Asian populations.
• These findings contribute to understanding the genetic underpinnings of periodontitis.