Related Experiment Video
Updated: Dec 27, 2025
Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
Published on: April 5, 2024
Maternal Obesity Programs Offspring Development and Resveratrol Potentially Reprograms the Effects of Maternal
Mei-Hsin Hsu1, Yu-Chieh Chen1, Jiunn-Ming Sheen1
1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Insights
Maternal obesity during pregnancy can negatively program offspring development, increasing adult obesity risks. Resveratrol shows promise in mitigating these adverse effects and reprogramming outcomes.
Area of Science:
- Reproductive Health
- Developmental Biology
- Nutritional Science
Background:
- Maternal obesity is a growing public health concern linked to rising adult obesity rates.
- Understanding the intergenerational impact of maternal obesity on offspring health is crucial for interventions.
Purpose of the Study:
- To review the programming effects of maternal obesity on offspring development.
- To explore underlying mechanisms and the potential role of resveratrol in mitigating these effects.
Main Methods:
- Literature review summarizing studies on maternal obesity and offspring outcomes.
- Analysis of evidence regarding maternal resveratrol supplementation and its impact.
Main Results:
- Maternal obesity adversely programs offspring development, contributing to long-term obesity.
- Evidence suggests maternal resveratrol consumption can alleviate consequences of maternal obesity.
Conclusions:
- Maternal obesity poses a significant risk for adverse offspring development and future obesity.
- Maternal resveratrol may serve as a potential therapeutic strategy to reprogram negative outcomes associated with maternal obesity.
Abstract:
Maternal obesity during pregnancy is a now a public health burden that may be the culprit underlying the ever-increasing rates of adult obesity worldwide. Understanding the association between maternal obesity and adult offspring's obesity would inform policy and practice regarding offspring health through available resources and interventions. This review first summarizes the programming effects of maternal obesity and discusses the possible underlying mechanisms. We then summarize the current evidence suggesting that maternal consumption of resveratrol is helpful in maternal obesity and alleviates its consequences. In conclusion, maternal obesity can program offspring development in an adverse way. Maternal resveratrol could be considered as a potential regimen in reprogramming adverse outcomes in the context of maternal obesity.
More Related Videos
11:44A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
Published on: September 27, 2017
06:11Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
Published on: May 17, 2024
Related Concept Videos
01:24Obesity
02:30Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...