Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protecting Groups for Aldehydes and Ketones: Introduction01:23

Protecting Groups for Aldehydes and Ketones: Introduction

8.6K
Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
8.6K
Catenins01:23

Catenins

2.9K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.9K
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

3.6K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
3.6K
Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

3.5K
Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous...
3.5K
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

5.5K
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
5.5K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.4K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weak Bond, Strong Response: Complete Activation and Efficient Cargo Release with a Furan/Acrylamide Mechanophore.

Journal of the American Chemical Society·2026
Same author

Template-Controlled Mechanochemical Dissociation of a Rotaxane.

Angewandte Chemie (International ed. in English)·2025
Same author

Force-Induced Ring Flipping in a Threaded Pillar[5]Arene.

Angewandte Chemie (International ed. in English)·2025
Same author

Selective Scission of Orthogonal Bonds in Four-Membered Ring Mechanophores upon Activation by a Rotaxane Actuator.

Angewandte Chemie (International ed. in English)·2025
Same author

A focus on substituents effect in the force-promoted disrotatory ring-opening of <i>cis</i>-cyclobutenes.

Chemical science·2025
Same author

A Mechanochromic Rotaxane that Releases Azetidine-Trityl-Maleimide, a Versatile Fluorescent Probe.

Angewandte Chemie (International ed. in English)·2025

Related Experiment Video

Updated: Dec 27, 2025

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
09:45

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene

Published on: March 20, 2017

10.8K

A Catenane as a Mechanical Protecting Group.

Min Zhang1, Guillaume De Bo1

  • 1Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

Journal of the American Chemical Society
|March 6, 2020
PubMed
Summary
This summary is machine-generated.

Mechanophores are molecules that respond to force. Researchers found that a [2]catenane acts as a mechanical shield, protecting active groups by distributing tension across its rings.

More Related Videos

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Published on: August 12, 2019

8.2K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

11.4K

Related Experiment Videos

Last Updated: Dec 27, 2025

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
09:45

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene

Published on: March 20, 2017

10.8K
Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Published on: August 12, 2019

8.2K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

11.4K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Polymer Chemistry

Background:

  • Mechanophores are molecules that exhibit changes in response to applied mechanical force.
  • The mechanical response of mechanophores can be modulated by altering their molecular structure or the surrounding polymer matrix.
  • Developing precise control over mechanophore activity is crucial for creating advanced force-responsive materials.

Purpose of the Study:

  • To investigate the potential of a [2]catenane as a mechanical protecting group for mechanophores.
  • To explore the force-diverting capabilities of the interlocked rings in a catenane system.
  • To establish a novel strategy for controlling the mechanical activation of mechanophores.

Main Methods:

  • Synthesis and characterization of a [2]catenane incorporating a mechanically active functional group.
  • Mechanical testing to evaluate the force-response of the functional group within the catenane framework.
  • Analysis of the catenane's ring mobility and its effect on tension distribution.

Main Results:

  • The [2]catenane effectively functioned as a mechanical protecting group.
  • Tensional forces were successfully diverted away from the embedded mechanophore by the catenane's mobile rings.
  • The rotation of the catenane rings allowed for tension equalization across the entire molecular framework.

Conclusions:

  • The mobility of the [2]catenane rings enables them to act as a mechanical shield, protecting embedded mechanophores.
  • This work introduces a new method for controlling mechanophore activity through supramolecular design.
  • The findings open avenues for developing sophisticated force-responsive materials with tunable mechanical behaviors.