Association of Adiponectin Genotypes With Colorectal Cancer Susceptibility in Taiwan
Related Experiment Video
Updated: Dec 27, 2025
Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice
Published on: January 24, 2025
Yi-Chih Hung1,2,3, Wen-Shin Chang1,3, An-Kuo Chou3,4
1Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
Aim:
To investigate the association between adiponectin (ADIPOQ) genotypes and colorectal cancer (CRC) risk among Taiwanese.
Materials And Methods:
Polymerase chain reaction-restriction fragment length polymorphism was adopted to identify ADIPOQ rs266729, rs2241766 and rs1501299 genotypes among 362 CRC patients and 362 healthy controls.
Results:
ADIPOQ rs266729 GG genotype (p=0.0075) and G allele (p=0.0061) are associated with a significantly increased CRC risk. There is no differential distribution of rs2241766 and rs1501299 genotypes. As for the gene-lifestyle interaction, there are obvious joint effects of rs266729 genotype on the CRC risk among non-smoker, non-alcohol drinker, while not on smoker or non-drinker subgroups. No significant correlation was observed between rs266729 genotypic distributions and age, gender, tumor size, location or metastasis status. Interestingly, a correlation of rs266729 genotype and larger BMI on CRC risk was found.
Conclusion:
G allele at ADIPOQ rs266729 may serve as a determiner for CRC risk, especially for those with BMI ≥24.
