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Published on: July 15, 2015
Changes in Serum Interleukin-8 and sRAGE Levels in Multiple Myeloma Patients
Alessandro Allegra1, Elisabetta Pace2, Gennaro Tartarisco3
1Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy aallegra@unime.it.
Background/Aim:
Although numerous cytokines influence proliferation and progression of multiple myeloma (MM), a relevant action in the onset of the disease also seems to be played by the oxidative state.
Patients And Methods:
In the present study we evaluated the concentrations of interleukin-8 (IL-8) and soluble receptor of advanced glycation end products (sRAGE) in patients with MM, assessing the existing variations with respect to a control group and the possible existence of correlations between these molecules and the biological variables or the presence of a correlation between IL-8 and sRAGE. The study was conducted on 33 patients affected by MM compared to 39 healthy subjects.
Results:
IL-8 and sRAGE levels were significantly higher in MM patients compared to healthy subjects. sRAGE and IL-8 evidence no significant linear correlation. Furthermore, IL-8 was significantly increased in both sexes, but we found a slight variation for females compared to males.
Conclusion:
IL-8 could play an important role in the onset of MM and the progression of bone disease, while the increased sRAGE values would seem to have a protective action in MM patients. Further studies on animal models may clarify the real impact of introducing modulation of IL-8 and sRAGE levels.
Insights
Interleukin-8 (IL-8) and soluble receptor of advanced glycation end products (sRAGE) were elevated in multiple myeloma (MM) patients. IL-8 may contribute to MM onset and bone disease, while sRAGE might offer protection.
Area of Science:
- Biochemistry
- Immunology
- Oncology
Background:
- Cytokines influence multiple myeloma (MM) progression.
- Oxidative stress may play a role in MM onset.
Purpose of the Study:
- Evaluate interleukin-8 (IL-8) and soluble receptor of advanced glycation end products (sRAGE) levels in MM patients.
- Compare MM patients to healthy controls.
- Assess correlations between IL-8, sRAGE, and MM characteristics.
Main Methods:
- Measured IL-8 and sRAGE concentrations in 33 MM patients and 39 healthy subjects.
- Analyzed variations between groups.
- Investigated correlations between molecules and biological variables.
Main Results:
- Significantly higher IL-8 and sRAGE levels in MM patients versus controls.
- No significant linear correlation between sRAGE and IL-8.
- IL-8 increased in both sexes, with slight variations observed in females.
Conclusions:
- IL-8 may be crucial in MM onset and bone disease progression.
- Elevated sRAGE suggests a protective role in MM.
- Further research, including animal models, is needed to clarify the impact of modulating IL-8 and sRAGE.
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