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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Issues And Trends In Healthcare Delivery System01:29

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Clinical Trials01:16

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Updated: Dec 27, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Navigating the Intersection between Genomic Research and Clinical Practice.

Mary B Daly1

  • 1Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. mary.daly@fccc.edu.

Cancer Prevention Research (Philadelphia, Pa.)
|March 6, 2020
PubMed
Summary
This summary is machine-generated.

The Risk Assessment Program (RAP) is exploring the return of research results to participants. Key issues include criteria for result selection, informed consent, and logistical challenges for genetic findings.

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Area of Science:

  • Oncology
  • Genetics
  • Bioethics

Background:

  • The Risk Assessment Program (RAP) is a large, multi-generational prospective cohort study at Fox Chase Cancer Center.
  • It collects extensive data on cancer history, risk factors, genetics, and biospecimens from over 10,000 individuals.
  • The program's research focuses on cancer gene characterization, interactions, and risk assessment strategies.

Purpose of the Study:

  • To review fundamental points for developing a policy on returning genetic research results to participants.
  • To address the ethical and practical challenges associated with providing clinically significant genetic findings from research.

Main Methods:

  • This is a review article, synthesizing current debates and considerations regarding the return of research results.
  • It examines the complexities arising from genetic discoveries within a large prospective cohort study.

Main Results:

  • Research is increasingly identifying genetic changes with potential clinical significance for study participants.
  • The need to establish clear guidelines for returning these research findings is paramount.

Conclusions:

  • Developing a paradigm for returning research results requires careful consideration of several key issues.
  • Essential elements include criteria for result selection, informed consent processes, and addressing logistical and cost challenges.