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Updated: Dec 27, 2025
06:39
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
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The glomerular crescent: triggers, evolution, resolution, and implications for therapy.
Lidia Anguiano1, Renate Kain, Hans-Joachim Anders
1Renal Division, Department of Medicine IV, University Hospital of the Ludwig Maximilian University, Munich, Germany Department of Pathology, Medical University of Vienna, Vienna, Austria.
Current Opinion in Nephrology and Hypertension
|March 6, 2020
Summary
Crescent formation in crescentic glomerulonephritis (CGN) involves activated parietal epithelial cells and vascular injury. Understanding these mechanisms is key to developing new therapies for CGN patients.
Area of Science:
- Nephrology
- Pathology
- Immunology
Background:
- Crescents are hallmark lesions of rapidly progressive glomerulonephritis (CGN).
- Crescent formation signifies severe kidney damage and GFR decline.
- Understanding CGN pathogenesis is crucial for patient management.
Purpose of the Study:
- To review the latest insights into crescent development in CGN.
- To explore the mechanisms driving crescent formation and resolution.
- To identify therapeutic targets for CGN.
Main Methods:
- Review of current literature on CGN pathogenesis.
- Analysis of molecular pathways involved in crescent formation.
- Discussion of upstream triggers and therapeutic interventions.
Main Results:
- Crescents arise from activated parietal epithelial cells (PECs) and vascular injury.
- Reversible cellular crescents can become irreversible fibrous crescents.
- Diverse upstream mechanisms, including vasculitis and glomerulonephritis, trigger PEC activation and complement involvement.
Conclusions:
- Identifying upstream mechanisms of crescent formation is vital for CGN therapy development.
- Targeting PEC activation and vascular injury offers therapeutic potential.
- Further research into CGN pathogenesis can improve patient outcomes.
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