Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circadian rhythm disruption and multiple sclerosis: The role of affective symptoms and temperamental traits.

Chronobiology international·2026
Same author

Beyond diagnosis: can fluid tau biomarkers stage Alzheimer's disease? Lessons from down syndrome.

EBioMedicine·2026
Same author

Plasma P-Tau217: A Powerful Alzheimer Disease Biomarker in the Right Clinical Context.

Neurology·2026
Same author

Can the integration of blood-based biomarkers into Alzheimer's disease diagnosis revolutionize the field?

Expert review of neurotherapeutics·2026
Same author

The contribution of Laboratory Medicine to Precision Neurology.

Clinical chemistry and laboratory medicine·2026
Same author

Transcriptome analysis of the prefrontal cortex identifies inflammatory genes associated with cognitive impairment in a model of multiple sclerosis.

Cell death discovery·2026

Related Experiment Video

Updated: Dec 27, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.9K

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis.

Lorenzo Gaetani1, Francesca Boscaro2, Giuseppe Pieraccini2

  • 1Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy.

Frontiers in Immunology
|March 6, 2020
PubMed
Summary

Researchers explored tryptophan metabolite patterns in multiple sclerosis (MS) patients. Identifying a unique urinary signature could lead to new biomarkers and drug targets for this central nervous system autoimmune disease.

Keywords:
indole-3-propionic acidkynureninemetabolitemicrobiotamultiple sclerosissignaturetryptophanurine

More Related Videos

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions
05:37

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

7.4K
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

1.1K

Related Experiment Videos

Last Updated: Dec 27, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.9K
Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions
05:37

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

7.4K
A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
09:52

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

1.1K

Area of Science:

  • Neuroimmunology
  • Metabolomics
  • Microbiome research

Background:

  • Multiple sclerosis (MS) is a central nervous system autoimmune disease characterized by demyelination and neuronal loss.
  • Tryptophan (Trp) metabolites and their associated enzymes are increasingly implicated in MS pathophysiology.
  • The kynurenine pathway synthesizes Trp metabolites with significant immunological and neuronal effects.

Purpose of the Study:

  • To investigate if a distinct urinary metabolic profile of host and microbiome-derived Trp metabolites exists in MS patients.
  • To explore the potential of these metabolic profiles as novel biomarkers for MS.
  • To identify specific metabolic pathways as potential therapeutic targets for MS treatment.

Main Methods:

  • Review and synthesis of existing literature on Trp metabolism in MS.
  • Analysis of studies reporting Trp metabolite levels in MS patients.
  • Discussion of host-microbiome interactions in Trp metabolism relevant to MS.

Main Results:

  • Trp metabolites, including those from the microbiome, are present and differentially regulated in MS patients.
  • Evidence suggests a potential for distinct urinary signatures related to Trp metabolism in MS.
  • The kynurenine pathway is a key focus due to its immunomodulatory and neuroactive metabolites.

Conclusions:

  • A specific urinary signature of host/microbiome tryptophan metabolism may be identifiable in multiple sclerosis patients.
  • Such a signature holds promise for the development of novel diagnostic biomarkers.
  • Targeting identified metabolic pathways could offer new therapeutic strategies for MS.