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Radiosurgery for Patients with More Than Ten Brain Metastases
Yoshihisa Kida1, Yoshimasa Mori2
1Neurological Surgery, Ookuma Hospital, Nagoya, JPN.
Cureus
|March 6, 2020
Summary
Gamma Knife radiosurgery is a viable treatment for patients with over 10 brain metastases, offering an alternative to whole-brain irradiation. Careful consideration of treatment time and radiation spillage is necessary for optimal outcomes.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Whole-brain irradiation is the standard for multiple brain metastases but carries risks of cognitive impairment.
- Patients often seek alternatives to whole-brain irradiation due to potential complications.
Purpose of the Study:
- To evaluate the efficacy and safety of Gamma Knife radiosurgery for patients with more than 10 brain metastases.
- To explore various treatment protocols for Gamma Knife radiosurgery in this patient population.
Main Methods:
- Review of 70 cases treated with Gamma Knife radiosurgery for brain metastases from various primary cancers.
- Application of diverse treatment protocols including single session, multi-session, fractionated irradiation, and salvage treatment.
Main Results:
- Gamma Knife radiosurgery was completed without major complications despite long beam-on-time and whole-brain spillage.
- Successful treatment was achieved across different protocols for patients with extensive brain metastases.
Conclusions:
- Stereotactic radiosurgery (SRS) or radiotherapy can be a treatment option for patients with over 10 brain metastases.
- Large metastatic foci may require pre- or post-radiosurgery removal due to long treatment times and radiation spillage.
