Bioequivalence data analysis for the case of separate hospitalization
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Updated: Dec 27, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Kyun-Seop Bae1, Seung-Ho Kang2
1Department of Clinical Pharmacology and Therapeutics Asan Medical Center, University of Ulsan, Seoul 05505, Republic of Korea.
Abstract:
A bioequivalence study is usually conducted with the same-day drug administration. However, hospitalization is occasionally separated for logistical, operational, or other reasons. Recently, there was a case of separate hospitalization because of difficulties in subject recruitment. This article suggests a better way of bioequivalence data analysis for the case of separate hospitalization. The key features are (1) considering the hospitalization date as a random effect than a fixed effect and 2) using "PROC MIXED" instead of "PROC GLM" to include incomplete subject data.
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