[Pharmacokinetic characteristics of a new drug form of diazepam--sibazon]

High-performance liquid chromatography, UV spectrometry and mass spectrometry have established that tablets of sibazon and seduxen contained equal quantities of pharmacologically active component diazepam. Radioligand assays revealed the diazepam blood serum levels twice as high 30 to 45 min after oral administration of seduxen than those after sibazon intake (p. less than 0.05). These differences were no more detectable after 2 to 3 hours. The pharmacokinetic differences could be accounted for by the properties of constituents.