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Related Experiment Video

Updated: Dec 27, 2025

A Microphysiologic Platform for Human Fat: Sandwiched White Adipose Tissue
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In vitro tissue-engineered adipose constructs for modeling disease.

Connor S Murphy1,2, Lucy Liaw1,2,3, Michaela R Reagan1,2,3

  • 1Maine Medical Center Research Institute, Scarborough ME.

BMC Biomedical Engineering
|March 6, 2020
PubMed
Summary

Tissue-engineered adipose tissue models offer versatile 3D platforms for studying diseases like obesity and diabetes. These models aid in understanding disease mechanisms and developing new therapies.

Keywords:
3D cultureIn vitro modelsadipocytescancerfatobesitytissue engineeringtissue-engineered adipose tissuetype 2 diabetes

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Cell Biology

Background:

  • Adipose tissue is crucial for insulation, energy storage, and endocrine signaling.
  • Tissue engineering of adipose tissue is vital for regenerative medicine applications.
  • Understanding adipose tissue function is key to metabolic and endocrine health.

Purpose of the Study:

  • To review the applications of tissue-engineered adipose tissue for disease modeling.
  • To describe three-dimensional (3D) in vitro adipose models for research.
  • To highlight the use of these models in obesity, diabetes, and cancer research.

Main Methods:

  • Review of existing literature on 3D adipose tissue engineering.
  • Description of various scaffold types (hydrogel, silk, scaffold-free).
  • Discussion of species of origin (human, mouse) and cell types used.

Main Results:

  • Diverse approaches exist for engineering 3D adipose models.
  • Models can be tailored for specific research applications, such as adipocyte differentiation.
  • These models facilitate the study of adipocyte interactions with other cell types, like endothelial cells.

Conclusions:

  • 3D in vitro adipose models are valuable tools for disease mechanism discovery.
  • These engineered tissues support the development of novel therapeutic strategies.
  • Applications include research into obesity, diabetes, and cancer therapies.