Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaginative play for inclusion: evaluating the young dragons tabletop role-playing intervention in UK schools.

BMC public health·2026
Same author

Effect of various modes of zinc application and different phosphorus doses on grain quality of wheat (<i>Triticum aestivum</i> L.).

Physiology and molecular biology of plants : an international journal of functional plant biology·2026
Same author

Electroencephalography during acute painful procedures in neonates: a scoping review.

Pain reports·2026
Same author

Landscaping evidence on first-line therapies for infantile epileptic spasms syndrome: An umbrella review.

Epilepsy research·2026
Same author

Predicting Surgical Outcome in Drug-Resistant Epilepsy by Combining Interictal Biomarkers within a Machine Learning Framework.

Research square·2026
Same author

Diagnostic Yield of Comprehensive Reanalysis After Nondiagnostic Short-Read Genome Sequencing in Infants With Unexplained Epilepsy.

Neurology·2026

Related Experiment Video

Updated: Dec 27, 2025

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.7K

Mortality in infantile spasms: A hospital-based study.

Chellamani Harini1, Elanagan Nagarajan1, Ann M Bergin1

  • 1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Epilepsia
|March 6, 2020
PubMed
Summary

Infantile spasms (IS) mortality is 17%, with persistent spasms and respiratory issues being key risk factors. Early deaths link to neurological issues, while later deaths show higher SUDEP rates.

Keywords:
SUDEPinfantile spasminfantile spasm mortalitymortality

More Related Videos

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

933
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.3K

Related Experiment Videos

Last Updated: Dec 27, 2025

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.7K
Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

933
Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.3K

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Research

Background:

  • Infantile spasms (IS) is a severe epilepsy syndrome in infants.
  • Understanding mortality risk factors in IS is crucial for patient management and care planning.

Purpose of the Study:

  • To identify risk factors and causes of mortality in children with infantile spasms.
  • To describe end-of-life care goals for deceased IS patients.

Main Methods:

  • Retrospective chart review of 150 IS patients born between 2000-2011.
  • Analysis of potential mortality risk factors including etiology, neurological impairment, medication, spasm persistence, and comorbidities.
  • Review of cause of death and end-of-life care for deceased patients.

Main Results:

  • Overall mortality was 17% (25/150), with 13 deaths before age 5.
  • Multivariate analysis identified persistent epileptic spasms (OR=4.30) and respiratory comorbidity (OR=12.75) as significant predictors of mortality.
  • Epilepsy-related deaths accounted for one-third of mortality, with Sudden Unexpected Death in Epilepsy (SUDEP) being more common in older children.
  • Respiratory failure was the primary cause of death in younger children (<5 years).

Conclusions:

  • Persistent epileptic spasms and respiratory comorbidities are major determinants of mortality in IS.
  • Mortality patterns differ by age, with neurological impairments/comorbidities dominating early deaths and SUDEP increasing in older children.
  • End-of-life care plans were documented for the majority of early mortality cases.