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Related Experiment Video

Updated: Dec 27, 2025

Probiotic Studies in Neonatal Mice Using Gavage
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Published on: January 27, 2019

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The lung microbiome in neonates.

Dhivya Lakshmi Permall1, Asfia Banu Pasha1, Xiao-Qing Chen1

  • 1Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, No 300, Guangzhou Road, Nanjing, Jiangsu Province.

The Turkish Journal of Pediatrics
|March 6, 2020
PubMed
Summary

The neonatal lung microbiome is understudied but crucial for respiratory health. Research suggests microbial imbalances are linked to infant lung diseases like bronchopulmonary dysplasia.

Keywords:
airwaybronchopulmonary dysplasialungmicrobiomenewborn

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Area of Science:

  • Neonatal medicine
  • Microbiology
  • Pulmonology

Background:

  • Studies on the neonatal lung microbiome are limited despite advances in culture-independent techniques.
  • The lung microbiome plays a role in the development of pulmonary conditions in newborns.
  • Understanding these microbial communities may lead to novel therapeutic strategies for preventing lifelong respiratory disability.

Purpose of the Study:

  • To review the current understanding of the lung microbiome in neonates.
  • To explore the association between the lung microbiome and neonatal pulmonary diseases.
  • To highlight the potential of targeting the airway and gut microbiomes for respiratory health.

Main Methods:

  • Literature review of studies on the neonatal lung microbiome.
  • Analysis of associations between microbial dysbiosis and specific neonatal lung conditions.
  • Exploration of the interplay between airway and gut microbiomes in respiratory health.

Main Results:

  • Bronchopulmonary dysplasia (BPD) is linked to reduced microbial diversity, the presence of Ureaplasma, and decreased Lactobacillus.
  • Microbial dysbiosis is implicated in the pathogenesis of asthma, cystic fibrosis, and pneumonia in newborns.
  • Interactions between airway and gut microbiomes are increasingly recognized for their impact on respiratory health.

Conclusions:

  • The neonatal lung microbiome is a critical area for research with significant therapeutic potential.
  • Further investigation into microbial dysbiosis is needed to develop targeted interventions for neonatal lung diseases.
  • Elucidating airway-gut microbiome interactions can broaden therapeutic approaches for respiratory conditions.