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Updated: Dec 27, 2025

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Long term follow-up of children with chronic hepatitis B: a single center experience

İnci Yaman Bajin1, Hülya Demir2, İnci Nur Saltık-Temizel2

  • 1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The Turkish Journal of Pediatrics
|March 6, 2020
PubMed

Insights

Combined treatment with Interferon (IFN) and lamivudine (LMV) showed the highest e-seroconversion rates in children with chronic Hepatitis B. Higher ALT levels correlated with better treatment response in this long-term study.

Area of Science:

  • Pediatrics
  • Hepatology
  • Virology

Background:

  • Chronic Hepatitis B infection poses significant risks for cirrhosis and hepatocellular carcinoma.
  • Optimal treatment strategies for pediatric chronic Hepatitis B remain debated.

Purpose of the Study:

  • To analyze the clinical features and long-term outcomes of children with chronic Hepatitis B.
  • To compare the effectiveness of different treatment protocols.

Main Methods:

  • Retrospective analysis of 165 children diagnosed with chronic Hepatitis B between 1993 and 2012.
  • Patients were categorized into four treatment groups: Interferon (IFN) only, Lamivudine (LMV) then IFN+LMV then LMV, IFN+LMV then LMV, and LMV only.
  • Median follow-up period of 7 years (range: 1-19 years).

Main Results:

  • Combined IFN+LMV treatment regimens demonstrated the highest rates of e-seroconversion, biochemical, and virological response.
  • Patients with elevated ALT levels exhibited a significantly better response to treatment (p: 0.003).

Conclusions:

  • Combined Interferon and Lamivudine therapy appears most effective for pediatric chronic Hepatitis B.
  • Identifying patients who require treatment is crucial for optimizing therapy and reducing long-term complications like cirrhosis and hepatocellular carcinoma.

Keywords:
childrenchronic hepatitis Btreatment

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