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Updated: Dec 27, 2025
Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers Diethylaminoethyl-cellulose Columns
Published on: April 6, 2019
Acyclic nucleoside phosphonates as possible chemotherapeutics against Trypanosoma brucei
1The School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072 QLD, Australia; Facultad de Ciencias e Ingeniería de Alimentos y Biotecnología, Universidad Técnica de Ambato, Ambato, Ecuador; Institute for Applied Sustainability Research, Av. Granados E13-55 e Isla Marchena, No.44, Quito 170503, Ecuador.
Abstract:
Human African trypanosomiasis is a life-threatening illness caused by Trypanosoma brucei. Owing to the toxic side effects of the available therapeutics, new medications for this disease are needed. One potential drug target is the 6-oxopurine phosphoribosyltransferases (PRTs), the activity of which is crucial to produce purine nucleotide monophosphates required for DNA and RNA synthesis. Inhibitors of the 6-oxopurine PRTs that show promising results as drug leads are the acyclic nucleoside phosphonates (ANPs). ANPs are very flexible in their structure, enabling important conformational changes to facilitate the binding of this class of compounds in the active site of the 6-oxopurine PRTs.
