Some cetyltrimethylammonium bromide modified polysaccharide supports as sustained release systems for curcumin

Area of Science:

• Medicinal Chemistry
• Materials Science
• Drug Delivery Systems

Background:

• Drug delivery systems are crucial in medicinal chemistry for localized action and sustained release.
• Polysaccharides offer potential for developing effective and novel drug delivery platforms.
• Curcumin, a natural compound, benefits from enhanced delivery systems due to its therapeutic properties.

Purpose of the Study:

• To develop and optimize novel sustained-release drug delivery systems for curcumin using five different polysaccharides.
• To investigate the efficacy of cetyltrimethylammonium bromide (CTAB) in modifying polysaccharides for enhanced drug release.
• To evaluate the biological activities and characterize the developed curcumin-loaded systems.

Main Methods:

• Development and optimization of five polysaccharide-based drug delivery systems.
• Modification of polysaccharides using cetyltrimethylammonium bromide (CTAB).
• Characterization using particle size analysis, FT-IR, and SEM; evaluation of sustained release via antioxidant, serum protein binding, and anti-cathepsin assays; chemical modeling studies.

Main Results:

• CTAB-modified NCCS, pectin-15, and Alg-5 demonstrated optimal sustained release of curcumin over extended periods.
• Characterization confirmed the successful modification of polysaccharide supports.
• Evaluated systems exhibited significant antioxidant, serum protein binding, and anti-cathepsin activities, indicating therapeutic potential.

Conclusions:

• Novel CTAB-modified polysaccharide systems (NCCS, pectin-15, Alg-5) are effective for sustained curcumin delivery.
• These systems show promising biological activities, supporting their potential in medicinal chemistry applications.
• The study highlights the utility of polysaccharides and CTAB in creating advanced drug delivery platforms.