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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Bladder Cancer, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology
Thomas W Flaig1, Philippe E Spiess2, Neeraj Agarwal3
1University of Colorado Cancer Center.
Summary
This summary of NCCN Guidelines for Bladder Cancer details updates on non-muscle-invasive and metastatic urothelial bladder cancer treatments. It includes strategies for bacillus Calmette-Guérin (BCG) shortages and biomarker testing for advanced disease.
Area of Science:
- Oncology
- Urology
Background:
- Bladder cancer management requires updated clinical guidelines.
- Recent advancements necessitate revisions in treatment protocols for urothelial carcinoma.
Purpose of the Study:
- To summarize key updates in the NCCN Clinical Practice Guidelines for Bladder Cancer.
- To provide guidance on the clinical presentation, workup, and treatment of bladder cancer, including non-muscle-invasive and metastatic stages.
Main Methods:
- Review of the NCCN Clinical Practice Guidelines for Bladder Cancer.
- Focus on updated sections concerning non-muscle-invasive and metastatic urothelial bladder cancer.
Main Results:
- Updated recommendations for non-muscle-invasive bladder cancer during bacillus Calmette-Guérin (BCG) shortages.
- Inclusion of biomarker testing details for advanced or metastatic urothelial bladder cancer.
- Revised systemic therapy recommendations for second-line or subsequent treatments.
Conclusions:
- The NCCN Guidelines provide critical updates for bladder cancer management.
- These updates address current challenges like BCG shortages and incorporate biomarker advancements for improved patient outcomes.
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