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Lipopolysaccharide-dependent enhancement of adherence-mediated chemiluminescence response of polymorphonuclear
A Dwenger1, G Schweitzer, M Funck
1Abteilung für Klinische Biochemie, Medizinische Hochschule Hannover, FRG.
Journal of Bioluminescence and Chemiluminescence
|January 1, 1988
Abstract:
Adherence of resting polymorphonuclear leukocytes to nylon fibre increased the chemiluminescence response (CL) from 99,400 to 910,300 cpm/25,000 PMNL. This effect could be amplified by lipopolysaccharide (LPS) priming of granulocytes in a dose-dependent fashion. The results of nylon fibre adherence experiments suggest an in vitro model that might approximate certain conditions of in vivo PMNL-endothelial adherence and respiratory burst activation, and these reactions of polymorphonuclear leukocytes may contribute to the pathomechanisms of the Adult Respiratory Distress Syndrome.