Related Experiment Video
Updated: Dec 27, 2025
Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy
1Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Korea.
Abstract:
Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-mediated protein complexes by interacting with themselves and other various cellular signaling molecules. These protein complexes help build tetraspanin-enriched microdomains (TEMs) that efficiently mediate intracellular signal transduction. In physiological conditions, TSPAN8 plays a vital role in the regulation of biological functions, including leukocyte trafficking, angiogenesis and wound repair. Recently, reports have increasingly shown the functional role and clinical relevance of TSPAN8 overexpression in the progression and metastasis of several cancers. In this review, we will highlight the physiological and pathophysiological roles of TSPAN8 in normal and cancer cells. Additionally, we will cover the current status of monoclonal antibodies specifically targeting TSPAN8 and the importance of TSPAN8 as an emerging therapeutic target in cancers for monoclonal antibody therapy.
Insights
Tetraspanin 8 (TSPAN8) is crucial for normal cell functions and cancer progression. Targeting TSPAN8 with monoclonal antibodies offers a promising new cancer therapy strategy.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Tetraspanin 8 (TSPAN8) is a cell surface protein involved in signaling complexes and microdomains.
- TSPAN8 regulates physiological processes like immune cell trafficking and wound repair.
- Overexpression of TSPAN8 is linked to cancer progression and metastasis.
Purpose of the Study:
- To review the physiological and pathophysiological roles of TSPAN8.
- To discuss the clinical relevance of TSPAN8 in various cancers.
- To explore TSPAN8 as a therapeutic target for monoclonal antibody therapy.
Main Methods:
- Literature review of TSPAN8's function in normal and cancer cells.
- Analysis of studies on TSPAN8 overexpression in cancer.
- Review of current monoclonal antibody therapies targeting TSPAN8.
Main Results:
- TSPAN8 is integral to tetraspanin-enriched microdomains (TEMs) mediating signal transduction.
- TSPAN8 overexpression correlates with increased cancer progression and metastasis.
- Monoclonal antibodies targeting TSPAN8 are under investigation for cancer treatment.
Conclusions:
- TSPAN8 plays a dual role in normal physiology and cancer pathophysiology.
- TSPAN8 represents a significant emerging therapeutic target for antibody-based cancer therapies.
More Related Videos
09:56A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
01:27Tumor Immunotherapy