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Methionine Restriction and Cancer Biology.

Desiree Wanders1, Katherine Hobson1, Xiangming Ji1

  • 1Department of Nutrition, Byrdine F. Lewis College of Nursing and Health Professions, Georgia State University, Atlanta, GA 30302, USA.

Nutrients
|March 7, 2020
PubMed
Summary
This summary is machine-generated.

Methionine restriction limits cancer cell growth and may boost chemotherapy effectiveness. This nutritional strategy impacts cancer biology through glutathione, polyamines, and methyl groups.

Keywords:
amino acidscancerglutathionemethioninemethylation

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Area of Science:

  • Oncology
  • Nutritional Science
  • Cancer Metabolism

Background:

  • Methionine, an essential amino acid, fuels cancer cell growth and metabolism.
  • Emerging evidence suggests methionine restriction inhibits cancer progression.
  • Methionine restriction may potentiate chemotherapy efficacy.

Purpose of the Study:

  • To review the efficacy and mechanisms of methionine restriction on cancer hallmarks.
  • To explore the role of key metabolic pathways in mediating these effects.
  • To discuss the translational potential for cancer patient treatment.

Main Methods:

  • In vitro and in vivo studies examining methionine restriction effects.
  • Analysis of cancer hallmarks under methionine-restricted conditions.
  • Review of literature on molecular mechanisms.

Main Results:

  • Methionine restriction inhibits cancer cell growth and proliferation.
  • Key mediators include altered glutathione formation, polyamine synthesis, and methyl group donation.
  • Evidence supports efficacy in both cell culture and animal models.

Conclusions:

  • Methionine restriction presents a viable strategy against cancer.
  • The mechanisms involve critical metabolic pathways influencing cancer biology.
  • Potential for personalized nutritional therapy in oncology.