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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Sample Size and Sampling Considerations in Published Clinical Research Articles.

Raakhi Tripathi¹, Nishtha Khatri², Ambika Mamde³

¹Associate Professor.

The Journal of the Association of Physicians of India

|March 7, 2020

Summary

This summary is machine-generated.

Reporting of sample size and sampling methods in clinical research is low, even in high-impact journals. Interventional studies showed better, but still inadequate, reporting of sample size calculations and sampling considerations.

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Area of Science:

Clinical Research Methodology
Biostatistics
Scientific Publication Standards

Background:

Accurate sample size calculation and appropriate sampling techniques are crucial for clinical research validity and generalizability.
Inadequate reporting of these elements can compromise study conclusions and limit the applicability of findings.

Purpose of the Study:

To assess the reporting standards of sample size and sampling considerations in clinical research articles published in 2017.
To identify disparities in reporting between high and low impact factor journals and across different study designs.

Main Methods:

A review of 264 clinical research articles from high and low impact factor journals across Medicine, Surgery, Obstetrics & Gynaecology, Paediatrics, and Pharmacology.
Analysis focused on the explicit reporting of sample size calculation/justification and sampling considerations (e.g., technique, participant follow-up, matching).

Main Results:

Overall reporting of sample size calculation was low (29.1% in interventional vs. 14.8% in observational studies).
High impact factor journals (33/155) and low impact factor journals (14/109) showed poor reporting of sample size justification.
Only 68 of 209 observational studies detailed sampling considerations.

Conclusions:

Reporting of sample size and sampling considerations remains inadequate across both high and low impact factor journals.
While interventional studies demonstrated better reporting, significant improvements are needed to enhance the rigor and transparency of clinical research.