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CAR T and CAR NK cells in multiple myeloma: Expanding the targets

Urvi A Shah1, Sham Mailankody1

  • 1Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Best Practice & Research. Clinical Haematology
|March 7, 2020
PubMed

Insights

Adoptive cell therapies, like CAR T-cell and CAR NK-cell therapies, show promise for treating advanced multiple myeloma (MM). Ongoing research focuses on novel targets and combination strategies to improve long-term remissions for MM patients.

Area of Science:

  • Hematology
  • Immunotherapy
  • Oncology

Background:

  • Multiple myeloma (MM) is a blood cancer with improved survival, but relapse remains a challenge.
  • Novel treatments are crucial for advanced MM, necessitating research into effective immunotherapies.
  • Recent approvals and ongoing development mark a new era for immunotherapy in MM treatment.

Purpose of the Study:

  • To review advancements in adoptive cell therapies for multiple myeloma.
  • To highlight clinical and translational progress in CAR T-cell and CAR NK-cell therapies.
  • To discuss emerging targets, manufacturing improvements, and combination strategies for MM treatment.

Main Methods:

  • Review of clinical trials and translational research in adoptive cell therapy for MM.
  • Focus on B-cell maturation antigen (BCMA) targeted therapies.
  • Analysis of manufacturing process changes and combination therapy trials.

Main Results:

  • First immunotherapies for MM approved in 2015, with many more in development.
  • Clinical trials are evaluating BCMA-targeted cellular therapies.
  • Research is exploring novel targets, earlier treatment lines, and combination approaches.

Conclusions:

  • Adoptive cell therapies, including CAR T-cell and CAR NK-cell therapies, represent a significant advancement in MM treatment.
  • Further research into novel targets, manufacturing, and combination therapies is essential for improving patient outcomes.
  • The development of off-the-shelf products could broaden accessibility to these innovative treatments.
Keywords:
Adoptive immunotherapyB-Cell maturation antigenCAR T-cell therapyChimeric antigen receptorsMultiple myeloma

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