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Updated: Dec 27, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[Bronchial smooth muscle mitochondria: A new target for asthma therapy?]
P Esteves1, A Celle1, P Berger2
1Université Bordeaux, centre de recherche cardio-thoracique de Bordeaux, U1045, CIC 1401, 33600 Pessac, France; Inserm, centre de recherche cardio-thoracique de Bordeaux, U1045, CIC 1401, 33600 Pessac, France.
Abstract:
The main purpose of this review is to highlight mitochondria as a new therapeutic target to prevent bronchial smooth muscle (BSM) remodeling in asthma. Severe asthmatic patients, representing 5-10% of all asthmatics, are characterized by an increased BSM mass which is highly correlated with the severity of the disease and the rate of exacerbations. None of the current asthma therapies are effective in reducing BSM remodelling. This review, based on the current literature, reports the role of mitochondria in BSM, particularly in calcium signaling.
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