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Updated: Dec 27, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Y-site Administration of Imipenem/Cilastatin/Relebactam With Common Intravenous Medications

Islam M Ghazi1, Wasim S El Nekidy2, Ayush Sood1

  • 1Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA.

Clinical Therapeutics
|March 7, 2020
PubMed
Abstract

Insights

Imipenem/cilastatin/relebactam is compatible with many intravenous drugs for Y-site administration. This finding supports its co-administration with other medications in critical care settings.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Imipenem/cilastatin/relebactam is approved for complicated infections and shows promise for hospital-acquired pneumonia.
  • Critically ill patients often require multiple intravenous medications, necessitating compatibility assessments.
  • Y-site compatibility is crucial for safe and effective co-administration of intravenous drugs.

Purpose of the Study:

  • To evaluate the physical compatibility of imipenem/cilastatin/relebactam when administered via Y-site with common intravenous medications.
  • To determine if co-administration poses risks of precipitation or significant pH changes.

Main Methods:

  • Imipenem/cilastatin/relebactam was prepared at 5 mg/mL.
  • Simulated Y-site administration by mixing equal volumes of imipenem/cilastatin/relebactam with other drugs.
  • Assessed physical compatibility, including pH and turbidity, over a 2-hour period.

Main Results:

  • Imipenem/cilastatin/relebactam demonstrated physical compatibility with a broad spectrum of tested intravenous medications.
  • The drug combination did not show significant signs of incompatibility during the observation period.

Conclusions:

  • Imipenem/cilastatin/relebactam can be co-administered with various intravenous medications via Y-site.
  • These compatibility findings facilitate clinical decision-making for managing multidrug-resistant infections in hospitalized patients.
Keywords:
Physical compatibilityY-site administrationimipenem/cilastatin/relebactamsimultaneous adminitration

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