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Updated: Dec 27, 2025
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Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR
Published on: November 23, 2012
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Complete Genome Sequence of Streptococcus ratti JH145
Sandra C Garrett1, Sara Olson2, Brenton R Graveley1
1Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, Connecticut, USA garrett@uchc.edu graveley@uchc.edu.
Microbiology Resource Announcements
|March 7, 2020
Summary
The complete genome of *Streptococcus ratti* JH145 was sequenced. This oral bacterium forms robust biofilms without producing cariogenic lactic acid, offering new insights for dental health research.
Area of Science:
- Microbiology
- Genomics
- Oral Health
Background:
- Streptococcus ratti is a cariogenic mutans streptococcus found in rat and human dental plaque.
- This species is implicated in dental caries development.
Purpose of the Study:
- To report the complete genome sequence of Streptococcus ratti strain JH145.
- To investigate the genetic basis for the unique non-cariogenic, biofilm-producing phenotype of strain JH145.
Main Methods:
- Whole-genome sequencing of Streptococcus ratti strain JH145.
- Bioinformatic analysis of the sequenced genome.
Main Results:
- The complete genome sequence of Streptococcus ratti strain JH145 is now available.
- Strain JH145 exhibits robust biofilm formation.
- Strain JH145 lacks the capacity to produce cariogenic lactic acid.
Conclusions:
- The genome sequence provides a valuable resource for understanding Streptococcus ratti biology.
- The unique phenotype of strain JH145 offers potential for novel oral health interventions targeting biofilm formation without promoting caries.
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