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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
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Low-Dose radiation therapy for benign pathologies.

Laura Torres Royo1, Gabriela Antelo Redondo2, Miguel Árquez Pianetta1

  • 1Radiation Oncology Department of Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili; Institut d'Investigació Sanitària Pere Virgili (IISPV), Spain.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
|March 7, 2020
PubMed
Summary
This summary is machine-generated.

Low dose radiotherapy (LD-RT) offers therapeutic benefits for benign conditions, expanding its clinical utility beyond cancer treatment. This review details LD-RT indications, dosages, and side effects for physicians.

Keywords:
Anti-InflammatoryAnti-ProliferationBenignLow dose radiationNon-MalignantRadio-Induced cancer risk

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Radiotherapy (RT) is a primary treatment for malignant tumors.
  • RT also demonstrates efficacy in treating benign pathologies.
  • Low and intermediate dose applications of RT are areas of ongoing research.

Purpose of the Study:

  • To review indications for low dose irradiation (LD-RT).
  • To discuss optimal total doses and fractionation schedules for LD-RT.
  • To analyze the secondary effects of LD-RT and identify suitable patient populations.

Main Methods:

  • Literature review of studies on low and intermediate dose radiotherapy.
  • Analysis of clinical data presented at the XX GOCO meeting.
  • Synthesis of information regarding indications, dosing, fractionation, and adverse events.

Main Results:

  • Established indications for LD-RT in various benign conditions.
  • Guidance on appropriate total doses and fractionation regimens.
  • Comprehensive analysis of potential secondary effects associated with LD-RT.

Conclusions:

  • LD-RT presents a viable therapeutic option for specific benign pathologies.
  • Understanding LD-RT parameters is crucial for effective and safe application.
  • This review aims to inform radiation oncologists and other physicians about LD-RT benefits and considerations.