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Chronic methyl bromide toxicity is ameliorated by haemodialysis

Nicole W M Khor1,2, Kirsten S Hepburn1,2, Angela L Chiew3

  • 1Department of Nephrology, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Internal Medicine Journal
|March 7, 2020
PubMed

Insights

Haemodialysis effectively treated chronic methyl bromide toxicity in a young man, improving neurological symptoms and reducing bromine levels. This case highlights haemodialysis as a viable treatment for prolonged methyl bromide exposure.

Area of Science:

  • Toxicology
  • Nephrology
  • Neurology

Background:

  • Methyl bromide is a volatile gas used in fumigation.
  • Chronic exposure can lead to significant neurotoxicity.
  • The efficacy of haemodialysis for chronic methyl bromide toxicity is not established.

Observation:

  • A 20-year-old male presented with chronic methyl bromide toxicity affecting the central nervous system.
  • The patient experienced neurotoxicity impacting the optic nerves, brain, and spinal cord.

Findings:

  • The patient underwent eight haemodialysis sessions.
  • Treatment resulted in reduced plasma bromine concentration and half-life.
  • Significant clinical recovery was observed post-haemodialysis.

Implications:

  • Haemodialysis is a potentially effective treatment for chronic methyl bromide toxicity.
  • This case expands treatment options for neurotoxic exposures.
  • Further research into haemodialysis for chronic toxic exposures is warranted.
Keywords:
dialysisnephrologyneuropathologyoccupational diseasetoxicology

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