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Updated: Dec 27, 2025

Design of an Open-Source, Low-Cost Bioink and Food Melt Extrusion 3D Printer
Published on: March 2, 2020
Semi-solid extrusion 3D printing ODFs: an individual drug delivery system for small scale pharmacy
Ting-Ting Yan1,2, Zhu-Fen Lv1,2, Pan Tian1,2
1Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, China.
Abstract:
Orodispersible films (ODFs) are promising drug delivery systems for customized medicines as it provide an alternative approach to increase consumer acceptance by advantages of rapid dissolution and administration without water. The aim of this study was to develop a platform to support the realization of tailored treatments suitable for the extemporaneous production of ODFs by semi-solid extrusion (SSE) 3D printing (3DP). Hydroxypropyl methyl cellulose (HPMC) was used as the polymer of ODFs, and levocetirizine hydrochloride was used as the model drug. The optimal formulation was HPMC:API:PS:maltitol:sucralose at a ratio of 64:10:10:15:1. Seventeen percent HPMC solution and optimal formulation were used to prepare film precursors. The impact of dynamic viscosities and fluid mechanics difference on printing applicability was discussed. The ODFs of cube designs with aimed dose of 1.25 mg, 2.5 mg, and 5 mg were printed by SSE 3DP. Good linear relationship between theoretical model volume and drug content (R2 = 0.999) and good dose accuracy indicate that 3DP is a suitable method for preparing individualized ODFs.
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