Related Experiment Video

Updated: Dec 27, 2025

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.1K

The potential mechanism of INHBC and CSF1R in diabetic nephropathy

X-Y Du1, B-T Zheng, Y Pang

  • 1Department of Nephrology, Jining No. 1 People's Hospital, Jining, P.R. China. zhoushiju@sina.com.

European Review for Medical and Pharmacological Sciences
|March 7, 2020
PubMed
Abstract

Insights

In diabetic nephropathy (DN), Inhibin beta C (INHBC) and Colony-stimulating factor 1 receptor (CSF1R) promote inflammation and inhibit apoptosis. Targeting INHBC and CSF1R may offer new therapeutic strategies for DN.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetic nephropathy (DN) is a major complication of diabetes mellitus.
  • Understanding the molecular mechanisms underlying DN is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the potential roles and mechanisms of Inhibin beta C (INHBC) and Colony-stimulating factor 1 receptor (CSF1R) in diabetic nephropathy.
  • To explore INHBC and CSF1R as potential therapeutic targets for DN.

Main Methods:

  • A diabetic nephropathy rat model was established using streptozotocin.
  • Blood glucose, insulin, biochemical markers, and inflammatory cytokines were analyzed.
  • Expression levels of INHBC, CSF1R, apoptosis-related proteins, and IGF-1 were assessed using Western blot and qPCR.

Main Results:

  • Diabetic nephropathy rats exhibited increased blood glucose, insulin, INHBC, CSF1R, IGF-1, IL-6, TNF-α, and Bcl2.
  • Levels of IL-10, Caspase 3, Caspase 9, and Bax were decreased in DN rats.
  • INHBC mRNA correlated positively with IGF-1 mRNA; CSF1R expression correlated with inflammatory and apoptotic markers.

Conclusions:

  • INHBC and CSF1R contribute to DN by inducing pro-inflammatory cytokines (IL-6, TNF-α), inhibiting anti-inflammatory cytokine (IL-10), suppressing apoptosis, and promoting renal cell proliferation.
  • INHBC and CSF1R represent promising therapeutic targets for managing diabetic nephropathy.

More Related Videos

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K
A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side09:58

A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side

Published on: May 6, 2016

14.8K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
363
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
2.4K