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INFLUENCE OF AGE-RELATED ANDROGEN DEFICIENCY ON THE RISK FACTORS ЕOF CARDIOVASCULAR DISEASES IN MEN WITH
T Krytskyy1, N Pasyechko1, N Yarema1
1I. Horbachevsky Ternopil National Medical University, Ukraine.
Georgian Medical News
|March 7, 2020
Summary
Men with hypothyroidism and androgen deficiency (AD) face higher cardiovascular risks. Low testosterone levels correlate with increased abdominal obesity, elevated triglycerides, and higher blood pressure, worsening heart disease risk factors.
Area of Science:
- Endocrinology
- Cardiology
- Men's Health
Background:
- Androgen deficiency (AD) in men with hypothyroidism is linked to cardiac issues, a leading cause of mortality.
- Cardiovascular disease (CVD) risk factors are a concern in hypothyroid men with AD.
- Understanding the interplay between AD, hypothyroidism, and CVD risk is crucial.
Purpose of the Study:
- To evaluate clinical signs of age-related AD.
- To investigate the association between AD and cardiovascular risk factors in men with hypothyroidism.
Main Methods:
- Radioimmunoassay analysis determined serum testosterone and sex hormone-binding globulin levels.
- Assessed lipid and carbohydrate metabolism, obesity type, depression levels, and daily blood pressure.
- Defined AD by serum total testosterone <12 nmol/L.
Main Results:
- Hypothyroid men with AD showed increased abdominal obesity, triglycerides, and glucose intolerance compared to those with normal testosterone.
- Subclinical depression was associated with decreased testosterone levels.
- Daytime blood pressure was significantly higher in hypothyroid men with AD.
Conclusions:
- Androgen deficiency negatively impacts cardiovascular risk factors in men with hypothyroidism.
- AD exacerbates metabolic and hemodynamic risk factors for heart disease in this population.
- Clinical attention to AD is warranted in hypothyroid men to mitigate cardiac pathology.
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