PRIMORDIAL FORMS OF PEYER'S PATCHES DEVELOPED IN ALBINO RATS' SMALL INTESTINE AFTER ADMINISTRATION OF BROAD-SPECTRUM...

Area of Science:

• Gastroenterology
• Immunology
• Microbiology

Background:

• Antibiotic-induced dysbiosis is a significant concern in morphological research.
• Understanding the impact of antibiotics on gut-associated lymphoid tissue is crucial.

Purpose of the Study:

• To investigate the early morphological changes in Peyer's patches in albino rats following clarithromycin administration.
• To explore the relationship between antibiotic use, dysbacteriosis, and the development of gut immune structures.

Main Methods:

• Experimental study involving 30 albino male rats.
• Administration of clarithromycin as a dietary supplement.
• Histological analysis of small intestine sections, focusing on Peyer's patches, using light microscopy and morphometry.

Main Results:

• Clarithromycin administration led to a significant increase in the number of Peyer's patches.
• Newly formed aggregated lymphoid nodules, considered primordial Peyer's patches, were observed in the intestinal mucosa.
• These changes are attributed to impaired small intestinal microbiocenosis caused by clarithromycin's broad-spectrum antibacterial and immunotropic effects.

Conclusions:

• Clarithromycin significantly alters the morphology of Peyer's patches in the small intestine.
• Antibiotic-induced dysbiosis can stimulate the formation of primordial Peyer's patches.
• This study provides insights into the immunotropic effects of clarithromycin on gut immune system development.