Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tooth Anatomy

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...

Teeth

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...

Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Public Perception of Fluoride: An Infodemiological Analysis of YouTube Videos and Comments.

JDR clinical and translational research·2026

Same author

Postoperative computed tomography segmentation with artificial intelligence for a closed-loop workflow in computer-assisted jaw reconstruction.

International journal of oral and maxillofacial surgery·2026

Same author

AI in Oral Health Surveillance: Critical Review.

Journal of dental research·2026

Same author

Association Between Solid Organ Transplantation and Oral Candidiasis: A Systematic Review and Meta-Analysis.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·2026

Same author

Emergent surgical airway for patients with head and neck conditions: a systematic review and meta-analysis.

International journal of oral and maxillofacial surgery·2025

Same author

Prophylactic Antibiotics for Prevention of Infective Endocarditis or Bacteremia in Pediatric Patients With Congenital Heart Disease Undergoing Dental Procedures: Systematic Review.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·2025

Search research articles

Related Experiment Video

Updated: Dec 26, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Topical Fluoride to Prevent Root Caries: Systematic Review with Network Meta-analysis.

J Zhang¹, D Sardana¹, K Y Li¹

¹The University of Hong Kong, Hong Kong.

Journal of Dental Research

|March 7, 2020

Summary

This summary is machine-generated.

Professionally applied 38% silver diamine fluoride (SDF) and self-applied 0.2% sodium fluoride (NaF) mouth rinse are most effective for preventing dental root caries. These topical fluorides significantly reduce caries increment compared to control groups.

Keywords:

aged dental caries evidence-based dentistry fluorides prevention systematic review

More Related Videos

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

Related Experiment Videos

Last Updated: Dec 26, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues

Published on: April 26, 2024

Area of Science:

Dentistry
Cariology
Preventive Dentistry

Background:

Dental root caries is a significant oral health concern, particularly in aging populations.
Effective preventive strategies are crucial for managing root caries progression.

Purpose of the Study:

To systematically review and network meta-analyze clinical evidence on professionally applied and self-applied topical fluorides for preventing dental root caries.
To identify the most effective fluoride agents and application methods.

Main Methods:

Systematic review and network meta-analysis of controlled clinical trials.
Searched major databases including MEDLINE, PubMed, Embase, Scopus, and Cochrane Library.
Included 9 trials with 4,030 participants, assessing 5 professionally applied and 7 self-applied topical fluoride agents.

Main Results:

Professionally applied 38% silver diamine fluoride (SDF), 5% sodium fluoride (NaF) varnish, and 1.2% acidulated phosphate fluoride reduced root caries increment by 0.59-0.85 mean decayed or filled root (DF-root) after 2 years.
Self-applied fluoride mouth rinse and toothpaste reduced root caries increment by 0.29-1.90 mean DF-root after 1 year.
Annual SDF application with oral health education and daily 0.2% NaF mouth rinse showed highest efficacy.

Conclusions:

Annual 38% silver diamine fluoride (SDF) solution combined with oral health education is the most effective professionally applied method for preventing dental root caries.
Daily use of 0.2% sodium fluoride (NaF) mouth rinse is the most effective self-applied method, followed by combined fluoride toothpaste and mouth rinse use.