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[Comparison of arterial and transcutaneous oxygen partial pressure in infants with bronchopulmonary dysplasia]
J P Praud1, E Dreizzen, A Carofilis
1Laboratoire de Physiologie, CNRS UA 1159, Hôpital Antoine-Béclère.
Insights
Transcutaneous PO2 (PTCO2) monitoring is a viable non-invasive method for assessing arterial oxygen levels (PaO2) in infants with bronchopulmonary dysplasia. This study found a significant correlation between PTCO2 and PaO2, suggesting its utility in clinical practice.
Area of Science:
- Neonatal Medicine
- Respiratory Physiology
- Medical Devices
Background:
- Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting infants.
- Accurate monitoring of arterial oxygenation is crucial for managing BPD.
- Transcutaneous PO2 (PTCO2) offers a potential non-invasive alternative to arterial PO2 (PaO2) measurements.
Purpose of the Study:
- To evaluate the correlation between transcutaneous PO2 (PTCO2) and arterial PO2 (PaO2) in infants with bronchopulmonary dysplasia.
- To determine the accuracy and reliability of PTCO2 as a measure of oxygenation in this vulnerable population.
Main Methods:
- A comparative study involving 19 infants diagnosed with bronchopulmonary dysplasia.
- PTCO2 measurements were taken using a Radiometer electrode heated to 44°C.
- PaO2 was measured simultaneously via a peripheral arterial line under standardized behavioral conditions.
- Data were collected from infants at various postnatal ages, including longitudinal assessments.
Main Results:
- A significant positive correlation was observed between PTCO2 and PaO2 (r = 0.73, p < 0.01).
- The regression equation was PTCO2 (mmHg) = 0.81 PaO2 + 5.2.
- The mean difference between PTCO2 and PaO2 was -7.2 mmHg, with a wide range (-34.5 to +33 mmHg).
- No significant relationship was found between the PTCO2-PaO2 difference and postnatal age within the studied range (r = -0.24, p > 0.1).
Conclusions:
- Transcutaneous PO2 (PTCO2) is significantly related to arterial PO2 (PaO2) in infants with bronchopulmonary dysplasia.
- PTCO2 can serve as a useful non-invasive tool for monitoring oxygenation in these infants.
- Further research may explore the clinical implications of the observed mean difference and range in PTCO2-PaO2 values.
Abstract:
Transcutaneous PO2 (PTCO2) (Radiometer electrode heated to 44 degrees C) was compared to arterial PO2 (PaO2) in 19 infants with bronchopulmonary dysplasia: 12 infants were tested once, at the mean postnatal age of 14 weeks (range 4-43 weeks), the other 7 infants were studied longitudinally from 5 weeks (range 2-8 weeks) to 12 weeks (range 6-18 weeks) of postnatal age. The protocol was standardized: measurement during behavioral stage 1, using a peripheral arterial line. Twenty-eight comparisons between PTCO2 and PaO2 were obtained. PTCO2 was significantly related to PaO2 [PTCO2 (mmHg) = 0.81 PaO2 + 5.2, r = 0.73, p less than 0.01]. The mean difference PTCO2 - PaO2 was -7.2 mmHg (range: -34.5 to + 33); in the studied age range the PTCO2 - PaO2 was not significantly related to postnatal age (r = -0.24; p greater than 0.1).